Research
View the research articles below that cover specific species research as well as more detailed information on our ingredients.
General
- Presumed neuroprotective therapies prescribed by veterinary ophthalmologists for canine degenerative retinal and optic nerve diseases
- An Oral Antioxidant Formulation Delaying and Potentially Reversing Canine Diabetic Cataract: A Placebo-controlled Double-masked Pilot Study
- Supplements for Exotic Pets
Alpha Lipoic Acid
- An Oral Antioxidant Formulation Delaying and Potentially Reversing Canine Diabetic Cataract: A Placebo-controlled Double-masked Pilot Study
- Behavioral Nutraceuticals and Diets.
- Alpha-lipoic acid prevents buthionine sulfoximine-induced cataract formation in newborn rats.
- Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid.
- alpha-Lipoic acid as a biological antioxidant.
- A current update on the use of alpha lipoic acid in the management of type 2 diabetes mellitus.
- Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests.
- New metabolic pathways of alpha-lipoic acid.
- alpha-Lipoic acid as a biological antioxidant.
- Therapeutic agents for the treatment of cognitive dysfunction syndrome in senior dogs.
- Pharmacokinetics of orally administered DL-?-lipoic acid in dogs.
- Therapy and outcome of suspected alpha lipoic acid toxicity in two dogs.
- Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles.
Arabinogalactan
Beta glucan
- Natramune and PureWay-C reduce xenobiotic-induced human T-cell alpha5beta1 integrin-mediated adhesion to fibronectin.
- The hemicellulose preparation, Natramune (PDS-2865), increases macrophage phagocytosis and nitric oxide production and increases circulating human lymphocytes levels.
- Pilot Study: The Affects of Natramune™ (PDS-2865®), a New Immunostimulator Supplement on Different Cetacean Species; Tursiops truncatus, Lagenorhynchus obliquidens, and Orcinus orca
- Natramune™ (PDS-2865®), an Immuno-stimulator Supplement in Cetaceans
- Evaluation of Imuno-2865® on General Rehabilitation Outcomes and Cytokine Profile Analysis in Abandoned Neonatal Harbor Seals (Phoca vitulina) and Malnourished Weanling Elephant Seals (Mirounga angustirostris)
- Supplementation with imuno-2865® in gilthead sea bream (Sparus aurata Linnaeus, 1758): Effects on hematological and antioxidant parameters
- Biochemical parameters in the blood of gilthead sea bream (Sparus aurata Linnaeus, 1758) supplemented with commercially available b-glucan-based product (IMUNO-2865 )
Boswellia serata
Calendula officinalis L.
Coenzyme Q10
- An Oral Antioxidant Formulation Delaying and Potentially Reversing Canine Diabetic Cataract: A Placebo-controlled Double-masked Pilot Study
- Metabolic, antioxidant, nutraceutical, probiotic, and herbal therapies relating to the management of hepatobiliary disorders.
- Coenzyme Q10 in the human retina.
- Coenzyme Q10 protects retinal cells against oxidative stress in vitro and in vivo.
- Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells.
- The potential value of natural antioxidative treatment in glaucoma.
Dioscorea sp. (yams)
Docosanol
Eleutherococcus senticosus
Glucosamine/Chondroitin
- [The influence of glucosamine on the antiexudative effect of nonsteroidal anti-inflammatory agents].
- Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials
- Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis.
- The role of glucosamine and chondroitin sulfate in treatment for and prevention of osteoarthritis in animals.
Grapeseed Extract
- An Oral Antioxidant Formulation Delaying and Potentially Reversing Canine Diabetic Cataract: A Placebo-controlled Double-masked Pilot Study
- Oligomeric proanthocyanidins (OPCs). Monograph.
- Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention.
- Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro.
- Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract.
- Procyanidin-rich extract from grape seeds prevents cataract formation in hereditary cataractous (ICR/f) rats.
- Effect of grape polyphenols on oxidative stress in canine lens epithelial cells.
- Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II.
- Antioxidant status modifications by topical administration of dorzolamide in primary open-angle glaucoma.
- Sensitivity of ocular anterior chamber tissues to oxidative damage and its relevance to the pathogenesis of glaucoma.
- Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells.
Green Tea Extract
- An Oral Antioxidant Formulation Delaying and Potentially Reversing Canine Diabetic Cataract: A Placebo-controlled Double-masked Pilot Study
- Black and green teas equally inhibit diabetic cataracts in a streptozotocin-induced rat model of diabetes.
- Orally administered epigallocatechin gallate attenuates light-induced photoreceptor damage.
- Orally administered epigallocatechin gallate attenuates retinal neuronal death in vivo and light-induced apoptosis in vitro.
- The potential value of natural antioxidative treatment in glaucoma.
Hypericum perforatum
- Hypericum perforatum treatment: effect on behaviour and neurogenesis in a chronic stress model in mice.
- Pharmacological studies in an herbal drug combination of St. John's Wort (Hypericum perforatum) and passion flower (Passiflora incarnata): In vitro and in vivo evidence of synergy between Hypericum and Passiflora in antidepressant pharmacological models
- St. John’s wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literature
L-5-hydroxy-tryptophan
Lutein/Zeaxanthin
- An Oral Antioxidant Formulation Delaying and Potentially Reversing Canine Diabetic Cataract: A Placebo-controlled Double-masked Pilot Study
- Resonance Raman measurement of macular carotenoids in normal subjects and in age-related macular degeneration patients.
- Ingestion of proanthocyanidins derived from cacao inhibits diabetes-induced cataract formation in rats.
- Dietary lutein stimulates immune response in the canine.
Lycopene
Methylsulfonylmethane (MSM)
- Assessment of methylsulfonylmethane (MSM) on the development of osteoarthritis (OA): An animal study
- Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model.
- Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial.
Omega-3 fatty acids
- An Oral Antioxidant Formulation Delaying and Potentially Reversing Canine Diabetic Cataract: A Placebo-controlled Double-masked Pilot Study
- Responses of dogs to dietary omega-3 fatty acids.
- Evidence for the effect of omega-3 fatty acids on progression of age-related macular degeneration: a systematic review.
- The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina.
- Multivitamin-multimineral supplements and eye disease: age-related macular degeneration and cataract.
- Relationship between plasma fatty acid profile and antioxidant vitamins during normal pregnancy.
- The Importance of Antioxidant Micronutrients in Pregnancy
- Effect of omega-3 fatty acids on canine atopic dermatitis.
- Omega-3 fatty acids in Boxer dogs with arrhythmogenic right ventricular cardiomyopathy.
- Positive impact of omega-3 fatty acid supplementation in a dog with drug-resistant epilepsy: a case study.
- A multicenter study of the effect of dietary supplementation with fish oil omega-3 fatty acids on carprofen dosage in dogs with osteoarthritis.
- The effect of dietary long-chain omega-3 fatty acid supplementation on owner's perception of behaviour and locomotion in cats with naturally occurring osteoarthritis.
- Essential fatty acids in mothers and their neonates.
St. John’s Wort
- Pharmacological studies in an herbal drug combination of St. John's Wort (Hypericum perforatum) and passion flower (Passiflora incarnata): in vitro and in vivo evidence of synergy between Hypericum and Passiflora in antidepressant pharmacological models.
- St. John’s wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literature
Triacontanol
Vitamin B1 (Thiamin)
Vitamin B3 (Niacin)
Vitamin B5 (Pantothenic acid)
Vitamin B6 (Pyridoxine)
Vitamin B7 (Biotin)
Vitamin B9 (Folate)
Vitamin B12 (Cobalamin)
Vitamin C
- An Oral Antioxidant Formulation Delaying and Potentially Reversing Canine Diabetic Cataract: A Placebo-controlled Double-masked Pilot Study
- Natramune and PureWay-C reduce xenobiotic-induced human T-cell alpha5beta1 integrin-mediated adhesion to fibronectin.
- A novel vitamin C preparation enhances neurite formation and fibroblast adhesion and reduces xenobiotic-induced T-cell hyperactivation.
- Moderate exercise combined with dietary vitamins C and E counteracts oxidative stress in the kidney and lens of streptozotocin-induced diabetic-rat.
- An ideal ocular nutritional supplement?
- Relation between lens opacities and vitamin and mineral supplement use.
- Nutritional antioxidants and age-related cataract and maculopathy.
- Ascorbic acid in aqueous humor and serum of patients with and without cataract; physiologic significance of relative concentrations.
- Antioxidant profile of cataractous English Cocker Spaniels.
Vitamin E
- An Oral Antioxidant Formulation Delaying and Potentially Reversing Canine Diabetic Cataract: A Placebo-controlled Double-masked Pilot Study
- Moderate exercise combined with dietary vitamins C and E counteracts oxidative stress in the kidney and lens of streptozotocin-induced diabetic-rat.
- An ideal ocular nutritional supplement?
- Vitamin E: maternal concentrations are associated with fetal growth.
Willow Bark Extract
Zinc
- An Oral Antioxidant Formulation Delaying and Potentially Reversing Canine Diabetic Cataract: A Placebo-controlled Double-masked Pilot Study
- The antioxidant properties of zinc: interactions with iron and antioxidants.
- Zinc and the special senses.
- Differentiation of soluble proteins in cataracts caused by deficiencies of methionine, riboflavin or zinc in diets fed to Atlantic salmon, Salmo salar, rainbow trout, Salmo gairdneri, and lake trout, Salvelinus namaycush.